Oncology
Novel Tumor-Targeted Self-Nanostructured and Compartmentalized Water-in-Oil-in-Water Polyurethane-Polyurea Nanocapsules for Cancer Theragnosis. Pharmaceutics. 2023 15(1), 58.
J. Bonelli, M. Velasco-de Andrés, N. Isidro, C. Bayó, S. Chumillas, L. Carrillo-Serradell, S. Casadó-Llombart, C. Mok, D. Benítez-Ribas, F. Lozano, J. Rocas and V. Marchán.
Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane–Polyurea Hybrid Nanocarrier. Biomacromolecules 2022, 23, 7, 2900–2913.
J. Bonelli, E. Ortega-Forte, A. Rovira, M. Bosch, O. Torres, C. Cuscó, J. Rocas, J. Ruiz and V. Marchán.
Polyurethane–polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(iii) metallodrugs. Inorganic Chemistry Frontiers. 2022; 9, 2123-2138.
J. Bonelli, E. Ortega-Forte, G. Vigueras, M. Bosch, N. Cutillas, J. Rocas, J. Ruiz and V. Marchán.
Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug. Biomedicines 2021, 9(5), 508.
M. Pérez-Hernández, C. Cuscó, C. Benítez-García, J. Bonelli, M. Nuevo-Fonoll, A. Soriano, D. Martínez-García, A. Arias-Betancur, M. García-Valverde, M. F. Segura, R. Quesada, J. Rocas, V. Soto-Cerrato and R. Pérez-Tomás.
Improved Pharmacokinetic Profile of Lipophilic Anti-Cancer Drugs Using Ανβ 3-Targeted Polyurethane-Polyurea Nanoparticles. Nanomedicine Nanotechnology, Biol. Med. 2018, 14 (2), 257–267.
P. Rocas, Y. Fernández, N. García-aranda, L. Foradada, P. Calvo, P. Avilés, M. José Guillén, S. Schwartz Jr, J. Rocas, F. Albericio, I. Abasolo.
Multifunctionalized polyurethane–polyurea nanoparticles: hydrophobically driven self-stratification at the o/w interface modulates encapsulation stability. Journal of Materials Chemistry, 2015, B 3 (42), 8421-8421.
P. Rocas, Y. Fernández, S Schwartz, I. Abasolo, J. Rocas, F. Albericio.
Other applications
Controlled Delivery of Redox Responsive Polyurethane-Polyurea Nanoparticles to Aortic ECs and Atherosclerotic Lesions. iScience, 2022, 25, 105390.
Y. Zhou, D. Hou, C. Cuscó, J. Bonelli, P. Rocas, J. Rocas, N. M. Hamberg, J. Han.
Nanoencapsulated Budesonide in Self-Stratified Polyurethane Polyurea Nanoparticles Is Highly Effective in Inducing Human Tolerogenic Dendritic Cells. Int. J. Pharm. 2016, 511 (2), 785–793.
G. Flórez-Grau, P. Rocas, R. Cabezón, C. España, J. Panés, J. Rocas, F. Albericio, D. Benítez-Ribas.
Multisensitive Drug-Loaded Polyurethane/Polyurea Nanocapsules with pH Synchronized Shell Cationization and Redox-Triggered Release. J. Polym. Chem. 2016, 7 (42), 6457–6466.
C. Cuscó, J. Garcia, E. Nicolás, P. Rocas, J. Rocas.
Installing Multifunctionality on Titanium with RGD-decorated Polyurethane-Polyurea Roxithromycin Loaded Nanoparticles: Towards New Osseointegrative Therapies. Advanced Healthcare Materials, 2015, 4, 13, 1956–1960.
P. Rocas, M. Hoyos-Nogués, J. Rocas, J. M. Manero, J. Gil, F. Albericio and C. Mas-Moruno.
Licensed IP
Nanotechnological platform based on polyurethane/polyurea chemistry to furnish water-oil-water multi walled and functionalizable nanocapsules and their preparation process. PCT/EP2022/058801, WO2022253483.
J. Bonelli Blasco, J. Rocas Sorolla.
Scientific Publications and IP Protection Policy
We seek for the excellence, so we are strictly compromised on the continuous evaluation of the work we performed by our peers. Our philosophy lies on scientific advance towards fruitful and synergistic collaborations, enhancing the level and making the research more visible. Innovation as a flagship. Intellectual Property are properly protected before public dissemination of project results.